Leptin is made from fat cells. People who are overweight tend to have more fat cells, and therefore have higher levels of leptin. Despite having such high levels of Leptin, the brain still doesn’t get the message that they are full and they should stop eating. Somehow, your body simply doesn’t respond to Leptin at all. This creates a problem, because the body is stuck in starvation mode. The person will continue to eat and will never feel satiated.
This problem can lead to obesity. This problem has the potential to worsen: the more obese you become, the more fat cells you make, and therefore the more Leptin you have in your body. Having large amounts of Leptin building up in the body is linked to a number of healthy problems, including obesity, high blood pressure, blood sugar problems, strokes, and heart disease.